Azilsartan medoxomil blocks the angiotensin II blazon 1 receptor preventing angiotensin II from bounden and causing vasoconstriction. Azilsartan's adeptness to abide deeply apprenticed to AT1 receptors for actual continued periods afterwards biologic accident is a part of its a lot of abnormal features.
Azilsartan medoxomil is anatomize to the alive metabolite azilsartan in the GI tract. The attendance of aliment does not affect articulate assimilation of azilsartan medoxomil, and the bioavailability is 60% for azilsartan. Maximum claret concentrations are accomplished in 1.5 to 3 hours.
Azilsartan medoxomil decreases the pressor aftereffect of angiotensin II. In response, angiotensin I, angiotensin II, and renin are added while aldosterone is decreased.