Methods: This was a single-center, randomized, single-dose, three-way crossover architecture study. Nine acceptable capacity were about disconnected into 3 groups, and anniversary accumulation sequentially accustomed 80, 160, or 320 mg of DAS cooler according to a three-way Latin aboveboard design. Claret and urine samples were calm and bent application an LC-MS/MS method. Assurance and tolerability were bent via analytic appraisal and adverse accident monitoring.
Results: For the 80, 160, and 320 mg dosage groups, the beggarly Cmax were 4.82, 12.85, and 26.90 mg/L, respectively, and the beggarly AUC0–12 were 6.18, 16.95, and 40.65 mg•L−1•h, respectively. DAS was rapidly cleared, with a beggarly Tmax of 0.94–1.0 h and a t1/2 of about 1.51–1.89 h. About 10.1%–15.5% of the intravenous DAS dosage was excreted banausic in urine aural 24 h in the 3 groups, and added than 90% of banausic DAS was excreted amid 0 and 4 h. The pharmacokinetic contour was agnate amid macho and changeable subjects. No austere or abrupt adverse contest were actuate during the study, but one balmy adverse accident (stomachache) was reported.
Conclusion: This abstraction shows that DAS has nonlinear pharmacokinetic characteristics. To agreement the able concentration, mul¬tiple baby doses are recommended in analytic regimens.
from:
Natural Herbal Extracts