Erlotinib HCl is a small molecule inhibitor of the human epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase. Overexpression of the EGFR is present in many carcinomas, and inhibition of the activating kinase by Erlotinib provides a chemical intervention upon these systems. The inhibition of this tyrosine kinase effectively blocks EGFR activity but does not suppress tumor growth. When combined with 3,3'-diindolylmethane (sc-204624), efficacy against tumor proliferation was demonstrated.
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