Direct role in myometrium to stimulate the pregnant uterus, the uterine muscle contraction, this contraction and contractions similar to full-term pregnancy and delivery, enough to cause abortion.Response of the uterine prostaglandin as the time of pregnancy and gradually increase, and will facilitate the expansion of the cervix softens.
Pharmacokinetic
Intra-amniotic administration of slowly absorbed into the systemic circulation, miscarriage average 20 to 24 hours, half-life of 3-6 hours in the amniotic fluid, intravenous half-life shorter than one minute. After intra-amniotic injection of 40mg, the peak blood concentration 3 ~ 7μg/ml, 6 to 10 hours, mean abortion time of about 20 to 24 hours, activity disappears and metabolites from enzymatic degradation in the lung and intrahepatic kidney, and about 5% with the feces.
[Pharmacology function] Dinoprost can be used directly acting on the myometrium, the uterine muscle contraction, leading to miscarriage.
Pharmacokinetic
This product is administered after the amniotic cavity are absorbed slowly into the systemic circulation, half of amniotic fluid is 3 ~ 6h, to eliminate the half-period of less than 1min (intravenous) in plasma.Degradation by enzyme inactivation in the lung and liver metabolite excretion from the kidneys, about 5% with the feces.
Indications
① trimester abortion (16-20 weeks), also applies to missed abortion, fetal death, intrauterine or congenital heart disease induction of labor; ② The low concentration of liquid intravenous infusion can be used in full-term pregnancy, induction of labor [J];angiography can be used as a vasodilator arterial injection.
This product is mainly used in the second trimester (16 to 20 weeks) abortion also applies to missed abortion, stillbirth induction of labor, full-term pregnancy when induction of labor. Arteriography as a vasodilator applications.
Usage and dosage for Dinoprost
Intra-amniotic administration, one injection rate of 40mg.
Preparation and specifications] to promise the forefront of the injection 4ml: 20mg (2) in (1) 8ml: 40mg
Intra-amniotic administration, once injected 40mg.
[Usage and dosage], intra-amniotic administration of the first injection of 5mg per minute injection rate does not exceed 1mg, no abnormal reaction, injection finished in 5min rest of 35mg. Can give such as abortion contractions has not yet formed, 6h 10 ~ 20mg, but membranes must not yet ruptured.
Amniotic fluid out of the bloody Never medication. To use other methods of induction of labor such as induction failure of this product required contractions stopped.
Formulations and specifications injection: 20mg/4ml, 40mg/8ml.
Adverse reactions of Dinoprost
Small number of patients, there may be phlebitis, symptoms disappeared after discontinuation. Also vomiting, mild diarrhea, fever rarely chills, headache, shivering.
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