Product Name: 2,4,5-TRIFLUOROPHENYL ACETIC ACID
English Synonyms:; 2,4,5-trifluoro phenyl acetic acid; 2,4,5-trifluoropheylacetic acid; (2,4,5-trifluorophenyl) acetic acid; 2,4,5-Trifluorophenylacetic acid; RARECHEM AL BO 0510; 2,4,5-trifluoromethyl phenyl acetic acid; Benzeneacetic acid, 2,4,5-trifluoro-;
Formula: C8H5F3O2
Molecular Weight: 190.1193
InChI: InChI = 1/C8H5F3O2/c9-5-3-7 (11) 6 (10) 1-4 (5) 2-8 (12) 13/h1, 3H, 2H2, (H, 12,13)
Density: 1.468g/cm3
Melting point: 121-125 ℃
Boiling Point: 255 ° C at 760 mmHg
Flash Point: 108 ° C
Preparation of intermediates involved in medicine, and particularly to preparation of 2,4,5 - trifluoro-acetic acid Preparation of fields. With 1,2,4 - fluorobenzene and paraformaldehyde and a chlorinating agent to obtain 2,4,5 - trifluoro-benzyl chloride, in a solvent to obtain cyanation 2,4,5 - trifluoro-benzonitrile in acidic or basic hydrolysis conditions reflux to give 2,4,5 - trifluoro-acetic acid the crude product by recrystallization to give 2,4,5 - trifluoro-acetic acid content of ≥ 99.9%. The present invention 2,4,5 - trifluoro acetic acid method of preparing synthetic route is short, mild conditions, easy to achieve industrialization and high product purity, stable quality, full compliance with the requirements for use as pharmaceutical intermediates.
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1.2,4,5 - Preparation of trifluoroacetic acid, wherein the synthetic route is implemented by the following: the specific steps: (1) 1,2,4 - fluorobenzene and paraformaldehyde is added chlorine agent for the reaction of chloromethyl 2,4,5 - trifluoro-benzyl chloride; (2) in the solvent cyanide reagent is added 2,4,5 - trifluoro-benzyl cyanide, chlorine, to give 2, 4,5 - trifluoro-benzonitrile; (3) 2,4,5 - trifluoro-benzonitrile in an acidic or alkaline aqueous solution heating hydrolysis, the reaction was completed, the post-treatment to give the product.
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From:Acridine Raw Material