Bakuchiol is a terpenophenolic compound extracted from the plant Psoralea corylifolia. Bakuchiol has been used as an articulate antibiotic, anti-tumor abettor and for the aegis of alarmist and cartilage tissue. It has aswell been used as an insulin enhancer to adverse hyperglycemia and hyperlipidemia for in vivo analysis on mice and rats. Within these studies, bakuchiol inhibited phospho-tyrosine protein phosphatase type 1B (PTP1B), DNA polymerase and topoisomerase II. Inactivity of these three enzymes abundantly bargain PTPB1 activity, which has been begin to abolish insulin signaling.
Antibiotic and anti-tumor uses of bakuchiol accept been crystalline to be activated to abolishment of DNA synthesis. As a antibacterial agent, bakuchiol has been accurate to be able-bodied in vitro and is anatomic at abounding pH ethics as able-bodied as in the attendance of organic acids. Bakuchiol terminates bacilli and cancerous beef by breeding intracellular acknowledging oxygen breed (ROS), dismantling bacterial beef and compromising bump corpuscle mitochondria. Conversely, bakuchiol has aswell been crystalline to bottle alarmist action by inhibiting ROS that could cause lipid peroxidation and the use of glutathione, an antioxidant.