Carmustine is a alacrity gas-related β-chloro-nitrosourea admixture acclimated as an alkylating abettor in chemotherapy. As a dialkylating agent, BCNU is able to anatomy interstrand crosslinks in DNA, which prevents DNA archetype and DNA transcription.
It has the actualization of an orange-yellow solid.
It is acclimated in the analysis of several types of academician blight (including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), assorted myeloma and lymphoma (Hodgkin's and non-Hodgkin). BCNU is sometimes acclimated in affiliation with alkyl guanine transferase (AGT) inhibitors, such as O6-benzylguanine. The AGT-inhibitors access the ability of BCNU by inhibiting the absolute changeabout alleyway of DNA repair, which will anticipate accumulation of the interstrand crosslink amid the N1 of guanine and the N3 of cytosine.
It is aswell acclimated as allotment of a chemotherapeutic agreement in alertness for hematological axis corpuscle transplantation, a blazon of cartilage bottom transplant, in adjustment to abate the white claret corpuscle calculation in the almsman (patient).
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