Molecular Formula:C14H11NO5
Molecular Weight:273.24
Tolcapone is a benzophenone acquired and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an agitator that catalyzes the metabolism of biologically alive catechols and their hydroxylated metabolites by appointment the methyl accumulation of S-adenosyl-L-methionine to the phenolic accumulation of catechol-containing substrates. When accustomed in affiliation with a borderline dopa decarboxylase inhibitor and levodopa, tolcapone may anticipate the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the academician and borderline tissues arch to added bioavailability and accessory of supply to the axial afraid arrangement (CNS) of levodopa.