Molecular Formula:C18H20O5
Molecular Weight:316.35
Assay.: 98%
Density: 1.184g/cm3
Melting point: 84.5-85.5°C
Boiling point: 490.3°C at 760 mmHg
Combretastatin A-4 is a combretastatin and a stilbenoid. It can be alone from Combretum caffrum, the Eastern Cape South African bushwillow timberline or in Combretum leprosum, the mofumbo, a brand activate in Brazil.
Combretastatin A-4 comes in two stereoisomers; The cis analysis binds abounding bigger to the 'colchicine' website on tubulin to arrest polymerization.
Combretastatin A-4 is the animate basal of combretastatin A-4 phosphate, a prodrug brash to blow the vasculature of bane tumors causing axial necrosis.
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